Guagnano is an Italian town of 5,925 inhabitants in the province of Lecce in Apulia. Located in the northern Salento, it also includes the hamlet of Villa Baldassarri at 2.5 km to the north-east. The territory of the municipality of Guagnano, located north of the provincial capital, covers an area of ??37 km ² on the border with the Province of Brindisi. The city center is located at 44 m ab ove sea level and is 24 km from Lecce.